STUDIEN UND PUBLIKATIONEN 2021 – HEUTE

„Publish or perish“ (englisch für „Veröffentliche oder gehe unter“) ist ein unter Wissenschaftler*innen gängiger Spruch. Er bringt zum Ausdruck, dass es zur Forschung gehört, eigene wissenschaftliche Befunde der wissenschaftlichen Öffentlichkeit bekannt zu machen. Dies dient zum einen dazu, über wissenschaftlichen Fortschritt zu informieren, damit aufbauend auf den neuen Erkenntnissen weitergeforscht werden kann. Zum anderen dient das Publizieren insbesondere in wissenschaftlichen Fachjournalen dazu, die Qualität der eigenen Arbeiten sicherzustellen und den Kontakt zur wissenschaftlichen Welt zu erlangen. Denn in Fachjournalen werden nur solche Artikel gedruckt, die einer kritischen Begutachtung durch anerkannte Fachleute standgehalten haben. Beiersdorf veröffentlicht seine Forschungsergebnisse seit Jahrzehnten in hochwertigen und anerkannten wissenschaftlichen Fachzeitschriften sowie in Form von Vorträgen und Postern auf Fachkongressen und stellt sich so dem kritischen Urteil der wissenschaftlichen Öffentlichkeit. Die große Zahl der Publikationen seit 1990 zeigt so äußerst eindrucksvoll, welches Gewicht die Beiersdorf Forschung in der weltweiten Hautforschung hat. 

2021

  • Roggenkamp D, Dlova N, Mann T, Batzer J, Riedel J, Kausch M, Zoric I, Kolbe L. Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol). Int. J. Cosmet. Sci. 2021; 43: 292-301 https://doi.org/10.1111/ics.12694
  • Roggenkamp D, Sammain A, Fürstenau M, Kausch M, Passeron T, Kolbe L. Thiamidol® in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase. J. Dermatol. 2021; 48 (12): 1871-1876 https://doi.org/10.1111/1346-8138.16080
  • Laudien M, Wensorra U, Roggenkamp D, Kolbe L, Schmidt L, Gallinger J, Warnke K, Weise J. Licochalcone A as powerful active partner for Thiamidol: Dual action against hyperpigmentation. Poster, 30th EADV Congress, Vienna 2021
  • Gallinger J, Rauscher C, Kuhn A, Dippe R, Dorsch S, Buerger A. Addressing an unmet cosmetical need: Effective solution to reduce both blemishes and acne-related post-inflammatory hyperpigmentation with a novel skin care formulation tailored for acne-prone skin containing the tyrosinase inhibitor Thiamidol. Poster, 30th EADV Congress, Vienna 2021
  • Gallinger J, Rauscher C, Kuhn A, Dippe R, Noelter A, Baumann S, Dorsch S, Buerger A. When 2 become 1: Effective reduction and prevention of blemishes and acne-related postinflammatory hyperpigmentation by two new formulations tailored for acne-prone skin combining Thiamidol efficacy, UV protection and antibacterial effect for improved quality of life. Poster, 30th EADV Congress, Vienna 2021
  • Kobylinski S, Reble C, Schanzer S, Gersonde I, Wiora G, Ploch NL, Karrer H, Kolbe L, Khazaka G, Lademann J, Meinke MC. Noninvasive measurement of the 308 nm LED-based UVB protection factor of sunscreens. J. Biophotonics 2021; 14: e202000453 https://doi.org/10.1002/jbio.202000453
  • Throm CM, Wiora G, Reble C, Schleusener J, Schanzer S, Karrer H, Kolbe L, Khazaka G, Meinke MC, Lademann J. In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source. J. Biophotonics. 2021;14: e202000348 https://doi.org/10.1002/jbio.202000348
  • Ruvolo E, Rohr M, Oliveira S, Nogueira L, Carvalho J, Cole C. Multi-laboratory study of hybrid diffuse reflectance spectroscopy to assess sunscreen SPF and UVA-PF. Photodermatol. Photoimmunol. Photomed. 2021; 37: 511–520 https://doi.org/10.1111/phpp.12703
  • Lyons AB, Zubair R, Kohli I, Nahhas AF, Braunberger TL, Mokhtari M, Ruvolo E, Lim HW, Hamzavi IH. Mitigating visible light and long wavelength UVA1-induced effects with topical antioxidants. Photochem. Photobiol. 2021; online ahead of print https://doi.org/10.1111/php.13525
  • Lim HW, Kohli I, Ruvolo E, Kolbe L, Hamzavi I. Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection. J. Amer. Acad. Dermatol. 2022; 86: S27-37 published online December 20, 2021 https://doi.org/10.1016/j.jaad.2021.12.024
  • Rigel D, Lim HW, Draelos Z, Weber TM, Taylor S. Photoprotection for all: Current gaps and opportunities. J. Amer. Acad. Dermatol. 2022; 86: S18-26 published online December 20, 2021 https://doi.org/10.1016/j.jaad.2021.12.023
  • Batzer J, Möller N, Bürger A, Balcke I, Kaack J, Wedel-Parlow M, Gallinger J, Weise J, Warnke K. Comparison of two in vitro methods regarding determination of physical protection against HEVIS stress. Poster, 30th EADV Congress, Vienna 2021
  • Warnke K, Möller N, Batzer J, Bürger A, Balcke I, Drescher P, Muhr G, Gallinger J, Weise J. More than sun protection – Combining Licochalcone A and color pigments for dual HEVIS protection. Poster, 30th EADV Congress, Vienna 2021
  • Gallinger J, Kohlhase S, Batzer J, Jung K, Bahr K, Kuhlmann I, Heinsohn G, Moeller N, Weise J, Buerger A, Schoelermann AM. Novel Medical Device with SPF 100 and very light and fluid texture developed for prevention of actinic keratosis and non-melanoma skin cancer. Poster, 30th EADV Congress, Vienna 2021
  • Schmidt L, Meiring U, Djamil J, Kuschel D, Drescher P, Dippe R, Warnke K. Closing a need gap – Effective dermocosmetic hand care targeting photoaging including lentigines solares with first visible results after 2 weeks. Poster, 30th EADV Congress, Vienna 2021
  • Zieger M, Kaatz M, Springer S, Riesenberg R, Wuttig A, Kanka M, Stanca S, Reble C, Khazaka G, Sieg R, De Gregorio M, Sattler M, Fischer F. Multi-wavelength, handheld laser speckle imaging for skin evaluation. Skin Res. Technol. 2021; 27: 486–493 https://doi.org/10.1111/srt.12959
  • Kern C, Speck U, Riesenberg R, Reble C, Khazaka G, Zieger M, Kaatz M, De Gregorio M, Fischer F. Mobile snapshot hyperspectral imaging device for skin evaluation using diffractive optical elements. Skin Res. Technol. 2021; 27: 589–598 https://doi.org/10.1111/srt.12991
  • Akinsinde LO, Glier TE, Schwartzkopf M, Betker M, Nissen M, Witte M, Scheitz S,  Nweze C, Grimm-Lebsanft B, Gensch M, Chumakov A, Baev I, Schürmann U, Dankwort T, Fischer F, Martins M, Roth SV, Kienle L, Rübhausen M. Surface characterization and resistance changes of silver-nanowire networks upon atmospheric plasma treatment. Appl. Surface Sci. 2021; 550: 149362 https://doi.org/10.1016/j.apsusc.2021.149362 
  • Holzscheck N, Falckenhayn C, Söhle J, Kristof B Siegner R, Werner A, Schössow J,  Jürgens C, Völzke H, Wenck H, Winnefeld M, Grönniger E, Kaderali L. Modeling transcriptomic age using knowledge-primed artificial neural networks. NPJ Aging Mechan. Disease 2021; 7:15 https://doi.org/10.1038/s41514-021-00068-5
  • Witte M, Rübhausen M, Jaspers S, Wenck H, Fischer F. A method to analyze the influence of mechanical strain on dermal collagen morphologies. Sci. Rep. 2021; 11: 7565 https://doi.org/10.1038/s41598-021-86907-7
  • Bussmann T, Warnke K, Krüger A, Möller N, Harbig S, Stuhr A, Dunckel J, Geloven van A, Weise J. Multifaceted novel approach to increase skin’s own epidermal and dermal hyaluron content. Poster, 30th EADV Congress, Vienna 2021
  • Geloven van A, Harbig S, Stuhr A, Dunckel J, Kuhn A, Dippe R, Warnke K. A holistic hyaluron-centric anti-aging concept to improve static and dynamic wrinkles. Poster, 30th EADV Congress, Vienna 2021
  • Worthmann A, Wessel S, Fuerstenau M, Schoelermann A, Gallinger J. Tailored for sensitive skin: A cleansing formulation with pH 5 mildly cleanses and protects sensitive skin and its microbiome. Poster, 30th EADV Congress, Vienna 2021
  • Schmidt L, Drescher P, Friemauth T, Ernst C, Sammain A, Gallinger J. A perfect match: The gold standard for dry skin plus anti-xerotic actives combined with a pleasant foam formulation – a holistic care approach for dry feet also in diabetes patients. Poster, 30th EADV Congress, Vienna 2021
  • Nickel K, Wensorra U, Wenck H, Peters N, Genth H. Evaluation of immunomodulatory responses and changed wound healing in type 2 diabetes—A study exploiting dermal fibroblasts from diabetic and non-diabetic human donors. Cells 2021; 10: 2931 https://doi.org/10.3390/cells10112931
  • Ahle CM, Stødkilde-Jørgensen K, Poehlein A, Streit WR, Hüpeden J, Brüggemann H. Comparison of three amplicon sequencing approaches to determine staphylococcal populations on human skin. BMC Microbiol. 2021; 21: 221 https://doi.org/10.1186/s12866-021-02284-1
  • Marcheggiani F, Kordes S, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Moller N, Blatt T, Weise JM, Damiani E, Tiano L. Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts. Free Rad. Biol. Med. 2021; 165: 282-288 https://doi.org/10.1016/j.freeradbiomed.2021.01.032
  • Nicol NH, Rippke F, Weber TM, Hebert AA. Daily moisturization for atopic dermatitis: Importance, recommendations, and moisturizer choices. J. Nurse Pract. 2021; 17: 920-925 https://doi.org/10.1016/j.nurpra.2021.06.003
  • Kordes S, Schulze M, Plennis A, Gallinger J, Filbry A, Weise J, Rippke F, Altgilbers S. Licochalcone A prevents inflammation-induced down-regulation of filaggrin gene expression in a 2D in vitro atopic dermatitis model. Poster, 30th EADV Congress, Vienna 2021
  • Laudien M, Welge V, Prokop M, Filbry A, Gallinger J, Weise J, Rippke F, Schulze M. A multifunctional moisturizer containing 10% urea plus NMF normalizes down-regulated epidermal gene expression in winter xerosis – Results of a novel in vitro approach. Poster, 30th EADV Congress, Vienna 2021
  • Altgilber S, Rippke F, Filbry A, Conzelmann S, Vietzke J-P, Burkhardt T, Segger D, Roggenkamp D, Grönniger E. A biomimetic combination of actives enhances skin hydration and barrier function via modulation of gene expression: Results of two double-blind, vehicle-controlled clinical studies. Skin Pharmacol. Physiol. 2021; online ahead of print https://doi.org/10.1159/000520009
  • Gallinger J, Kuhn A, Wessel S, Behm P, Heinecke S, Filbry A, Hillemann L, Rippke F. Depth-dependent hydration dynamics in human skin – Vehicle-controlled efficacy assessment of a functional 10% Urea plus NMF moisturizer by Near-Infrared Confocal Spectroscopic Imaging (KOSIM IR) and capacitance method complemented by volunteer perception. Skin Res. Technol. 2022; 1-8 published online December 2021, 18 https://doi.org/10.1111/srt.13137
  • von Martial S, Nippel G, Schmidt L, Sammain A, Schölermann A, Presto S, Tsianakas A. Einfluss einer adjuvanten Basistherapie mit 10% Urea, Ceramiden, Glycerin und Glyceryl Glucoside bei Patienten mit Psoriasis vulgaris. Hautarzt 2021; 72: 892–899 https://doi.org/10.1007/s00105-021-04833-1
  •  Gregoire S, Sorrell I, Lange D, Najjar A, Schepky A, Ellison C, Troutman J, Fabian E, Duplan H, Genies C, Jacques-Jamin C, Klaric M, Hewitt NJ. Cosmetics Europe evaluation of 6 in silico skin penetration models. Comput. Toxicol. 2021; 100177 https://doi.org/10.1016/j.comtox.2021.100177
  • Hamadeh A, Troutman J, Najjar A, Edginton A. A mechanistic bayesian inferential workflow for estimation of in vivo skin permeation from in vitro measurements. J. Pharm. Sci. 2021; online ahead of print https://doi.org/10.1016/j.xphs.2021.11.028
  • Bury D, Alexander-White C, Clewell III HJ, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A. New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine. Regul. Toxicol. Pharmacol. 2021; 123: 104931 https://doi.org/10.1016/j.yrtph.2021.104931
  • Lester C, Hewitt NJ, Müller-Vieira U, Mayer M, Ellison C, Duplan H, Genies C, Jacques-Jamin C, Fabian E, Sorrell I, Lange D, Schepky A Gregoire S. Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models. Toxicol. in Vitro 2021; 72: 105051 https://doi.org/10.1016/j.tiv.2020.105051
  • Ouedraogo G, Mahony C, Naciff J, Klaric M, Hewitt NJ, Kenna G, Schepky A, Krüger CT, Dent M, Vandenbossche E, Keller D. Integrating toxicokinetics and toxicodynamics for decision-making in an NGRA context: 2 Cosmetics-Europe case studies (abstr. 377).  MECC Maastricht 2021
  • Ellison CA, Api AM, Becker RA, Efremenko AY, Gadhia S, Hack CE, Hewitt NJ, Varcin M, Schepky A. Internal threshold of toxicological concern (iTTC): Where we are today and what is possible in the near future. Front. Toxicol. 2021; 2: 621541 https://doi.org/10.3389/ftox.2020.621541
  • Adriaens E, Verstraelen S, Desprez B, Alepee N, Abo T, Bagley D, Hibatallah J, Mewes KR, Pfannenbecker U, Van Rompay AR. Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method with regard to solid and liquid chemicals testing. Toxicol. In Vitro 2021; 70: 105044 https://doi.org/10.1016/j.tiv.2020.105044
  • Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I. Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model. Toxicol. 2021; 448: 152637 https://doi.org/10.1016/j.tox.2020.152637
  • Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J. Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin–liver microphysiological model. J. Appl. Toxicol 2021; 41:1553–1567 https://doi.org/10.1002/jat.4146
  • Wilm A, Norinder U, Agea MI, de Bruyn Kops C, Stork C, Kühnl J, Kirchmair J. Skin Doctor CP: Conformal prediction of the skin sensitization potential of small organic molecules. Chem. Res. Toxicol. 2021; 34: 330-344 https://dx.doi.org/10.1021/acs.chemrestox.0c00253
  • Wilm A, de Lomana MG, Stork C, Mathai N, Hirte S, Norinder U, Kühnl J, Kirchmair J. Predicting the skin sensitization potential of small molecules with machine learning models trained on biologically meaningful descriptors. Pharmaceuticals 2021; 14: 790 https://doi.org/10.3390/ph14080790